GEN1 Antikörper (AA 61-111)

Produktnummer ABIN8121631

Der Kaninchen Polyklonal anti-GEN1 Antikörper (ABIN8121631) detektiert spezifisch GEN1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für GEN1 Antikörper (AA 61-111) (ABIN8121631)

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GEN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GEN1 Antikörper

Bindungsspezifität: AA 61-111

Verwendungszweck: GEN Antibody

Spezifität: This antibody detects endogenous levels of GEN at Human/Mouse

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human GEN AA range: 61-111

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu GEN1

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Andere Bezeichnung: GEN

Hintergrund:

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains.The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],

Gene Name: GEN1

Protein Name: GEN

Gen-ID: 348654

UniProt: Q17RS7

Pathways: DNA Reparatur