C1S Antikörper (Cleaved-Ile438, Light Chain)

Produktnummer ABIN8120712

Der Kaninchen Polyklonal anti-C1S Antikörper wird verwendet zum Nachweis von C1S in Proben von Human, Ratte und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für C1S Antikörper (Cleaved-Ile438, Light Chain) (ABIN8120712)

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C1S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-C1S Antikörper

Bindungsspezifität: Cleaved-Ile438, Light Chain

Verwendungszweck: C1S (light chain, Cleaved-Ile438) Antibody

Spezifität: This antibody detects endogenous levels of Human C1S (light chain, Cleaved-Ile438, protein was cleaved amino acid sequence between 437-438 )

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human C1S (light chain, Cleaved-Ile438)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000 ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Andere Bezeichnung: C1S

Hintergrund:

Synonyms: Complement C1s subcomponent (EC 3.4.21.42, C1 esterase, Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain]

Background: catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580], that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,

Gene Name: C1S

Protein Name: C1S (light chain, Cleaved-Ile438)

Gen-ID: 716

UniProt: P09871

Pathways: Komplementsystem