CTNND1 Antikörper (AA 600-700)

Produktnummer ABIN8120249

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch CTNND1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CTNND1 Antikörper (AA 600-700) (ABIN8120249)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CTNND1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: AB1487

Produktdetails anti-CTNND1 Antikörper

Bindungsspezifität: AA 600-700

Verwendungszweck: p120 catenin Rabbit mAb (Ready to Use)

Spezifität: The antibody can specifically recognize human p120 catenin protein.

Aufreinigung: The antibody was purified by protein A affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human p120 catenin protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: It has been optimized for direct use, requiring no further dilution.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C. Avoid freeze.

Details zu CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Andere Bezeichnung: p120 catenin

Hintergrund:

Synonyms: Cadherin associated Src substRate,Cadherin-associated Src substRate,CAS,Catenin (cadherin associated protein) delta 1,Catenin delta 1,Catenin delta,Catenin delta-1,CTND1_HUMAN,CTNND 1,CTNND,CTNND1,delta 1 Catenin,KIAA0384,p120,P120 CAS,p120 catenin,P120 CTN,p120 (cas) ,p120 (ctn) ,P120CAS,P120CTN

Background: α- Catenin, β- Catenin, γ- catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E- cadherin. P120 catenin binds to the near membrane region of E- cadherin to form a complex, which is stable and closely linked. In lobular breast cancer, E- cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm, while in ductal breast cancer, p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore, it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.

Gene Name: CTNND1

Protein Name: p120 catenin

Gen-ID: 1500

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling