beta Amyloid Antikörper (AA 221-270)

Produktnummer ABIN8119707

Der Kaninchen Polyklonal anti-beta Amyloid Antikörper wird verwendet zum Nachweis von beta Amyloid in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und IF.

Kurzübersicht für beta Amyloid Antikörper (AA 221-270) (ABIN8119707)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: AA 221-270

Verwendungszweck: Amyloid-β Antibody

Spezifität: Amyloid-β Polyclonal Antibody detects endogenous levels of Amyloid-β

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Amyloid-beta at AA range: 221-270

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid-beta

Hintergrund:

Synonyms: amyloid beta (A4) precursor protein

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],

Gene Name: APP A4 AD1

Protein Name: Amyloid beta A4 protein, Amyloid-β, Aβ

Gen-ID: 351

UniProt: P05067

Pathways: Inflammasome