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p107 Antikörper (pThr369) (Biotin)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch p107 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN760693

Kurzübersicht für p107 Antikörper (pThr369) (Biotin) (ABIN760693)

Target

Alle p107 (RBL1) Antikörper anzeigen
p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reaktivität

  • 73
  • 18
  • 9
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 70
  • 3
Kaninchen

Klonalität

  • 71
  • 2
Polyklonal

Konjugat

  • 32
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser p107 Antikörper ist konjugiert mit Biotin

Applikation

  • 60
  • 33
  • 27
  • 27
  • 10
  • 9
  • 6
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 17
    • 15
    • 8
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr369

    Kreuzreaktivität

    Human

    Homologie

    Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human p107 around the phosphorylation site of Thr369

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

    Andere Bezeichnung

    p107

    Hintergrund

    Synonyms: RBL1phospho T369, 107 kDa retinoblastoma-associated protein, Cellular protein 107, Cellular protein p107, CP107, MGC40006, p107, PRB1, RBL1, RBL1_HUMAN, Retinoblastoma like protein 1, retinoblastoma-like 1 p107, Retinoblastoma-like protein 1.

    Background: p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

    Gen-ID

    5933

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases
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