TEK Antikörper (AA 700-1000)

Produktnummer ABIN8093513

Der Maus Monoklonal anti-TEK Antikörper wird verwendet zum Nachweis von TEK in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für TEK Antikörper (AA 700-1000) (ABIN8093513)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TEK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TEK-9412

Produktdetails anti-TEK Antikörper

Bindungsspezifität: AA 700-1000

Verwendungszweck: TIE2 Antibody / TEK

Immunogen: A recombinant fragment (around amino acids 700-1000) of human TEK protein (exact sequence is proprietary) was used as the immunogen for the Angiopoietin Receptor/TIE2 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Angiopoietin Receptor/TIE2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Angiopoietin Receptor/TIE2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Andere Bezeichnung: TIE2

Hintergrund: Angiopoietin Receptor antibody, also known as TIE2 antibody, recognizes a receptor tyrosine kinase encoded by the TEK gene. This protein is commonly referred to as TIE2, TEK receptor tyrosine kinase, CD202b, and Tunica interna endothelial cell kinase in the literature. TIE2 is a transmembrane receptor primarily expressed in vascular endothelial cells, where it regulates angiogenesis, vascular remodeling, and endothelial cell survival.

TIE2 belongs to the receptor tyrosine kinase family and contains extracellular immunoglobulin-like domains, epidermal growth factor-like repeats, fibronectin type III domains, a single transmembrane region, and an intracellular tyrosine kinase domain. Binding of its ligands, Angiopoietin-1 and Angiopoietin-2, induces receptor dimerization and autophosphorylation, leading to activation of downstream pathways including PI3K-AKT and MAPK signaling. These cascades promote endothelial quiescence, vessel maturation, and maintenance of vascular integrity.

During embryogenesis, TIE2 signaling is essential for vascular network formation and stabilization. In adult tissues, it maintains endothelial barrier function and regulates vascular permeability. Dysregulated Angiopoietin-TIE2 signaling contributes to tumor angiogenesis, inflammatory disorders, diabetic retinopathy, and vascular malformations. Activating mutations in the TEK gene have been linked to inherited venous malformations, emphasizing the receptor’s importance in vascular biology.

TIE2 is predominantly localized to the plasma membrane of endothelial cells, with activated receptor complexes undergoing internalization and cytoplasmic signaling. Because of its endothelial-restricted expression profile, Angiopoietin Receptor antibody is widely used in research applications to evaluate vascular structures and angiogenic signaling pathways. An Angiopoietin Receptor antibody can be used to detect TIE2 expression in endothelial biology and tumor angiogenesis research.

UniProt: Q02763

Pathways: RTK Signalweg, Growth Factor Binding