Rekombinanter SOX10 Antikörper (AA 115-269)

Produktnummer ABIN8093490

Der Maus Monoklonal anti-SOX10 Antikörper (Klon rSOX10-13506) (ABIN8093490) detektiert spezifisch SOX10 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Rekombinanter SOX10 Antikörper (AA 115-269) (ABIN8093490)

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: RSOX10-13506

Produktdetails anti-SOX10 Antikörper

Bindungsspezifität: AA 115-269

Verwendungszweck: SOX10 Antibody / SRY-box transcription factor 10

Immunogen: Recombinant human SOX10 protein fragment (around amino acids 115-269) (exact sequence is proprietary) was used as the immunogen for the SRY-box transcription factor 10/SOX10 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SRY-box transcription factor 10/SOX10 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: SRY-box transcription factor 10/SOX10 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Andere Bezeichnung: SOX10

Hintergrund: SRY-box transcription factor 10 Antibody recognizes SOX10, a nuclear DNA-binding protein encoded by the SOX10 gene and belonging to the SOX family of high mobility group box transcription factors. SOX10 contains a conserved HMG-box domain that enables sequence-specific DNA binding and transcriptional activation of genes essential for neural crest development and lineage specification. This transcription factor localizes predominantly to the nucleus, consistent with its regulatory role in gene expression programs controlling cell fate determination.

SOX10 plays a critical role during embryogenesis, where it regulates neural crest cell survival, migration, and differentiation. It is indispensable for formation of melanocytes, Schwann cells, peripheral glial cells, and elements of the enteric nervous system. In melanocyte biology, SOX10 functions upstream of MITF and influences pigmentation pathways by regulating genes involved in melanin synthesis and melanocyte maintenance. In peripheral nerve development, SOX10 contributes to Schwann cell maturation and myelination through interaction with signaling pathways including Wnt, Notch, and neuregulin-mediated mechanisms.

In adult tissues, SOX10 expression is largely restricted to melanocytes within the basal epidermis and hair follicles and to Schwann cells associated with peripheral nerves. This lineage-restricted distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell populations. Nuclear staining is characteristic of SOX10 detection and reflects its function as a transcription factor.

SOX10 has significant relevance in oncology research. Expression is frequently observed in melanoma, malignant peripheral nerve sheath tumors, and clear cell sarcoma, where nuclear staining supports identification of melanocytic or neural crest differentiation. SOX10 expression has also been reported in subsets of triple-negative breast carcinoma and salivary gland tumors exhibiting basal-like or myoepithelial characteristics. Dysregulated SOX10 activity may contribute to tumor progression and cellular plasticity in melanoma and related malignancies.

SRY-box transcription factor 10 Antibody / SOX10 (clone rSOX10/13506) is a recombinant monoclonal antibody suitable for detecting SOX10 protein expression in research applications focused on neural crest biology, melanocyte differentiation, peripheral nerve studies, and tumor characterization.

UniProt: P56693

Pathways: Chromatin Binding