PEX16 Antikörper (N-Term)

Produktnummer ABIN8093405

Der Kaninchen Polyklonal anti-PEX16 Antikörper wird verwendet zum Nachweis von PEX16 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF und IP.

Kurzübersicht für PEX16 Antikörper (N-Term) (ABIN8093405)

Target: PEX16 (Peroxisomal Biogenesis Factor 16 (PEX16))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEX16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-PEX16 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: PEX16 Antibody / Peroxisomal biogenesis factor 16

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Peroxisomal biogenesis factor 16 was used as the immunogen for the PEX16 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PEX16 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PEX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PEX16

Target: PEX16 (Peroxisomal Biogenesis Factor 16 (PEX16))

Andere Bezeichnung: PEX16

Hintergrund: PEX16 antibody targets Peroxisomal biogenesis factor 16, encoded by the PEX16 gene. Peroxisomal biogenesis factor 16 is a peroxisomal membrane protein that plays a key role in early stages of peroxisome membrane formation and maintenance. Unlike shuttling import receptors, PEX16 functions as a membrane-associated organizer that contributes to the establishment and stabilization of peroxisomal membranes.

Functionally, Peroxisomal biogenesis factor 16 participates in the recruitment and insertion of other peroxisomal membrane proteins, supporting the assembly of functional peroxisomes. It has been implicated in coordinating peroxisome membrane biogenesis from pre-existing peroxisomes or precursor membrane structures. A PEX16 antibody supports studies focused on peroxisome membrane formation, organelle biogenesis, and intracellular membrane trafficking.

PEX16 is predominantly localized to peroxisomal membranes, consistent with its role as a structural and organizational component rather than a transport receptor. Its membrane-associated distribution distinguishes it from matrix protein import receptors and reflects its involvement in shaping peroxisomal architecture. Through this role, Peroxisomal biogenesis factor 16 contributes indirectly to peroxisome-dependent metabolic processes, including lipid metabolism and reactive oxygen species regulation.

From a disease-related perspective, disruption of PEX16 function impairs peroxisome formation and has been linked to peroxisome biogenesis disorders. Loss of functional PEX16 compromises peroxisomal membrane integrity and downstream metabolic capacity, highlighting its importance in organelle development and cellular homeostasis. These findings make PEX16 a relevant target for studies of inherited metabolic disease and organelle dysfunction.

At the molecular level, Peroxisomal biogenesis factor 16 contains conserved membrane-associated regions that support its localization and interactions with other peroxins. Its apparent behavior in biochemical assays reflects its membrane-embedded nature rather than changes in protein structure or processing. PEX16 antibody reagents enable investigation of peroxisomal membrane biogenesis and organelle assembly, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9Y5Y5