Rekombinanter D-Dimer Antikörper

Produktnummer ABIN8093124

Der Kaninchen Monoklonal anti-D-Dimer Antikörper (Klon FGG-13043R) (ABIN8093124) detektiert spezifisch D-Dimer in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter D-Dimer Antikörper (ABIN8093124)

Target: D-Dimer

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser D-Dimer Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Klon: FGG-13043R

Produktdetails anti-D-Dimer Antikörper

Verwendungszweck: D-dimer Antibody / Cross-linked fibrin fragment (azide and preservative free)

Immunogen: Recombinant human FGA protein (exact sequence is proprietary) was used as the immuongen for the D-dimer antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: 1. Optimal dilution of the D-dimer antibody should be determined by the researcher.

2. This D-dimer antibody is recombinantly produced by expression in CHO cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: D-dimer antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu D-Dimer

Target: D-Dimer

Hintergrund: D-dimer antibody targets a neoantigenic epitope present on the cross-linked fibrin fragment known as D-dimer, a specific fibrin degradation product generated during active coagulation and fibrinolysis. D-dimer is formed only after fibrinogen is converted to fibrin by thrombin, fibrin strands are covalently cross-linked by factor XIIIa, and the stabilized clot is subsequently cleaved by plasmin. This multistep requirement makes D-dimer a highly specific molecular marker of clot formation and breakdown rather than a marker of native fibrinogen or unprocessed fibrin.

D-dimer is derived primarily from the gamma chain region of fibrinogen (FGG) following cross-linking and proteolytic cleavage, creating a unique conformational epitope that is absent in intact fibrinogen, non-cross-linked fibrin, or individual fibrinogen chains. Antibodies directed against this neoepitope selectively recognize cross-linked fibrin degradation products, providing high specificity for biologically relevant clot turnover. As a result, D-dimer antibody reagents are fundamentally different from antibodies raised against fibrinogen alpha, beta, or gamma chains, which detect native circulating proteins rather than processed clot fragments.

The biological significance of D-dimer lies in its role as a direct indicator of ongoing or recent coagulation activity. Elevated D-dimer levels reflect activation of both the coagulation cascade and the fibrinolytic system, making D-dimer a widely used biomarker in thrombosis research and clinical diagnostics. D-dimer antibody tools are extensively applied in studies of venous thromboembolism, disseminated intravascular coagulation, cardiovascular disease, inflammation-associated coagulopathy, cancer-associated thrombosis, and sepsis-related clotting abnormalities.

In tissue-based and biochemical research, D-dimer antibody reagents are used to detect fibrin deposition and degradation within vascular and extravascular compartments. Localization of D-dimer-positive material provides insight into sites of active clot formation, fibrinolytic remodeling, and vascular injury. In cancer and inflammatory disease models, detection of cross-linked fibrin fragments can reveal interactions between coagulation pathways, immune cell infiltration, and tissue remodeling processes within the disease microenvironment.

The D-dimer antibody clone FGG/13043R is designed to recognize a neoantigenic determinant specific to the D-dimer fragment of cross-linked fibrin. Clone FGG/13043R does not detect native fibrinogen or uncleaved fibrin, supporting its use in research applications that require selective identification of fibrin degradation products. This monoclonal antibody enables precise investigation of coagulation dynamics, clot resolution, and fibrinolytic activity in physiological and pathological experimental systems.

UniProt: P02679