Rekombinanter Cathepsin G Antikörper (N-Term)

Produktnummer ABIN8093040

Der Maus Monoklonal anti-Cathepsin G Antikörper (Klon r19C3) (ABIN8093040) detektiert spezifisch Cathepsin G in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Cathepsin G Antikörper (N-Term) (ABIN8093040)

Target: Cathepsin G (CTSG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin G Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: R19C3

Produktdetails anti-Cathepsin G Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CTSG Antibody / Cathepsin G

Immunogen: Prokaryotic recombinant protein corresponding to a 124 amino acid N-terminal region of the cathepsin G molecule was used as the immunogen for the CTSG/Cathepsin G antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: 1. Optimal dilution of the CTSG/Cathepsin G antibody should be determined by the researcher.

2. This CTSG/Cathepsin G antibody is recombinantly produced by expression in CHO cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: CTSG/Cathepsin G antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu Cathepsin G

Target: Cathepsin G (CTSG)

Andere Bezeichnung: CTSG

Hintergrund: CTSG antibody targets Cathepsin G, a serine protease encoded by the CTSG gene and predominantly expressed in neutrophils and other myeloid lineage cells. Cathepsin G is stored in azurophilic granules and released during neutrophil activation, where it participates in antimicrobial defense, extracellular matrix remodeling, and regulation of inflammatory responses. CTSG antibody is widely used to study innate immune cell function and neutrophil-associated proteolytic activity.

Cathepsin G localizes primarily to cytoplasmic granules in resting neutrophils and can be detected extracellularly following degranulation. In addition to neutrophils, Cathepsin G expression has been reported in monocytes, mast cells, and certain epithelial cells under inflammatory conditions. Once released, Cathepsin G can cleave a broad range of substrates, including bacterial proteins, extracellular matrix components, and host signaling molecules. CTSG antibody detection is therefore relevant for investigations into immune defense and tissue remodeling processes.

Functionally, Cathepsin G exhibits both proteolytic and regulatory activities. It contributes directly to pathogen killing while also modulating cytokines, chemokines, and cell surface receptors involved in immune cell recruitment and activation. Through these actions, Cathepsin G influences leukocyte migration, vascular permeability, and inflammatory signaling cascades. CTSG antibody reagents support research into protease-driven regulation of innate immunity and inflammation.

Dysregulated Cathepsin G activity has been implicated in a variety of pathological conditions, including chronic inflammatory diseases, cardiovascular disorders, and cancer. Excessive CTSG activity can contribute to tissue damage and fibrosis, while altered expression patterns have been observed in inflammatory lesions and tumor microenvironments. These associations underscore the value of CTSG antibody-based detection in studies examining inflammatory pathology and immune-mediated tissue injury.

Clone r19C3 is designed to recognize Cathepsin G in research applications. CTSG antibody reagents are suitable for detecting protein expression and localization in immune cells and tissue samples, supporting studies focused on neutrophil biology, inflammatory protease activity, and disease-associated alterations in innate immune responses.

UniProt: P08311

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones