CAMK2B Antikörper (pThr305)

Produktnummer ABIN757447

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CAMK2B in WB, ELISA, IF (cc), IF (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CAMK2B Antikörper (pThr305) (ABIN757447)

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMK2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CAMK2B Antikörper

Bindungsspezifität: pThr305

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Sheep,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CaMK2 alpha around the phosphorylation site of Thr305

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CAMK2B

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Andere Bezeichnung: CaMK2

Hintergrund:

Synonyms: alpha CaMKII, Calcium / Calmodulin Dependent Protein Kinase II G, Calcium calmodulin dependent protein kinase CaM kinase II alpha, Calcium calmodulin dependent protein kinase II alpha-B subunit, Calcium calmodulin dependent protein kinase II, Calcium/calmodulin dependent protein kinase II alpha, Calcium/calmodulin-dependent protein kinase CaM kinase II alpha, Calcium/calmodulin-dependent protein kinase II alpha, Calcium/calmodulin-dependent protein kinase II-alpha, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Calcium/calmodulin-dependent protein kinase type IIA, CaM kinase II alpha chain, CaM kinase II alpha subunit, CaM kinase II beta chain, CaM kinase II beta subunit, CaM kinase II delta chain, CaM kinase II delta subunit, CaM kinase II subunit alpha, CAM2, CaMK II alpha subunit, CaMK II beta subunit, CaMK II delta subunit, CaMK-II subunit alpha, CAMK2A, CAMK2B, CAMK2D, CAMKA, CAMKB, CaMKII, EC 2.7.11.17, KIAA0968, MGC123320, MGC139375, MGC155201, mKIAA0968, PK2CDD, PKCCD, KCC2A_HUMAN.

Background: Ca2+/CalmodulinDependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.

Gen-ID: 816

Pathways: WNT Signalweg, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity