FCN1 Antikörper (AA 95-314)

Produktnummer ABIN8065464

Der Maus Monoklonal anti-FCN1 Antikörper wird verwendet zum Nachweis von FCN1 in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für FCN1 Antikörper (AA 95-314) (ABIN8065464)

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCN1 Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 5

Produktdetails anti-FCN1 Antikörper

Bindungsspezifität: AA 95-314

Verwendungszweck: Anti-M-Ficolin Antibody

Spezifität: ABS 036-05 reacts specifically with M-Ficolin.

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Recombinant human M-Ficolin (aa 95 to 314)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu FCN1

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Andere Bezeichnung: M-Ficolin

Hintergrund: FCN1, FCNM, ficolin-1, M-ficolin, ficolin (collagen/fibrinogen domain-containing) 1, ficolin-A, ficolin-alpha,Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:17897951, ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}.,FCN1,M-Ficolin (Ficolin-1) is a non-serum protein that is expressed in leukocytes and lung. M-Ficolin precipitates with mannose-binding lectin (MBL)-associated serine proteases (MASP)-1 and MASP-2, indicating that M-Ficolin forms complexes with MASP-1 and MASP-2, recognizes certain types of bacteria and subsequently activates the lectin pathway.

Molekulargewicht: 35 kDa

Gen-ID: 2219

UniProt: O00602

Pathways: Komplementsystem