Ficolin 2 Antikörper

Produktnummer ABIN8065462

Der Maus Monoklonal anti-Ficolin 2 Antikörper (Klon 19) (ABIN8065462) detektiert spezifisch Ficolin 2 in WB, IP und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Ficolin 2 Antikörper (ABIN8065462)

Target: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Ficolin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Güteklasse: Carrier-free

Klon: 19

Produktdetails anti-Ficolin 2 Antikörper

Verwendungszweck: Anti-L-Ficolin Antibody

Spezifität: ABS 005-19 reacts specifically with L-Ficolin. No cross reactivity is seen with M-Ficolin (Ficolin-1) and H-Ficolin (Ficolin-3).

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Purified procaryot expressed recombinant human L-Ficolin and full-length L-Ficolin (Ficolin-2) protein.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu Ficolin 2

Target: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Andere Bezeichnung: L-Ficolin

Hintergrund: FCN2, EBP-37, FCNL, P35, ficolin-2, ficolin-2, 37 kDa elastin-binding protein, L-ficolin, collagen/fibrinogen domain-containing protein 2, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), ficolin B, ficolin-beta, serum lectin p35,Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:10679061, PubMed:14707097, PubMed:15804047, PubMed:17215869, PubMed:25344472, PubMed:8576206). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:14707097). Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens (PubMed:14707097, PubMed:17215869, PubMed:25344472, PubMed:8576206). Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect (PubMed:8576206). {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:14707097, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:25344472, ECO:0000269|PubMed:8576206}.,FCN2,L-Ficolin (Ficolin-2) is an innate immunity pattern recognition molecule found in human serum. L-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP), such as carbohydrates (GlcNAc), lipoteichoic acid and acetylated groups thereby facilitating phagocytosis and activation of complement through the lectin route using the same serine proteases as mannose-binding lectin (MBL) named MASP ((MBL)-associated serine protease) (1).

Molekulargewicht: 35 kDa

Gen-ID: 2220

UniProt: Q15485

Pathways: Komplementsystem