D-Dimer Antikörper

Produktnummer ABIN8065446

Der Maus Monoklonal anti-D-Dimer Antikörper wird verwendet zum Nachweis von D-Dimer in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für D-Dimer Antikörper (ABIN8065446)

Target: D-Dimer

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser D-Dimer Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 22

Produktdetails anti-D-Dimer Antikörper

Verwendungszweck: Anti-D-Dimer Antibody

Spezifität: ABS 015-22 binds human D-dimer. Cross-reacts < 2 % with directly coated D-monomer but not with directly coated fibrinogen. When tested in a pair with itself, with ABS 015-28 and with a fibrinogen-specific polyclonal antibody, the epitope appears to relate to the dimerization site of D-dimer.

Homologie: Canine,Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Purified human D-dimer

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 12 months

Details zu D-Dimer

Target: D-Dimer

Hintergrund: FGA, AMYLD2, Fib2, fibrinogen alpha chain, fibrinogen, A alpha polypeptide, FGB, HEL-S-78p, fibrinogen beta chain, beta-fibrinogen, epididymis secretory sperm binding protein Li 78p, fibrinogen, B beta polypeptide, FGG, fibrinogen gamma chain, fibrinogen, gamma polypeptide, testicular tissue protein Li 70,Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways,FGA, FGB, FGG,D-dimer is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.

Molekulargewicht: 180 kDa

Gen-ID: 2243, 2244, 2266

UniProt: P02671, P02675, P02679