Adrenomedullin Antikörper

Produktnummer ABIN8065421

Dieser Maus Monoklonal Antikörper detektiert spezifisch Adrenomedullin in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Adrenomedullin Antikörper (ABIN8065421)

Target: Adrenomedullin (ADM)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Adrenomedullin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Güteklasse: Carrier-free

Klon: 1

Produktdetails anti-Adrenomedullin Antikörper

Verwendungszweck: Anti-Adrenomedullin Antibody

Spezifität: ABIN8065421 binds human adrenomedullin and shows no cross-reaction with CGRP. The epitope of ABIN8065421 lies within residues 22-52.

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Synthetic human adrenomedullin 1-52

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu Adrenomedullin

Target: Adrenomedullin (ADM)

Andere Bezeichnung: Adrenomedullin

Substanzklasse: Hormone

Hintergrund: ADM, AM, PAMP, pro-adrenomedullin, preproadrenomedullin, proadrenomedullin N-20 terminal peptide,Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. {ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Adrenomedullin]: Peptide hormone that act as potent hypotensive and vasodilatator agents (PubMed:8387282). ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex (PubMed:32296767, PubMed:9620797). {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Proadrenomedullin N-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563). {ECO:0000269|PubMed:15823563, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}., [Proadrenomedullin 9-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875). {ECO:0000269|PubMed:15823563, ECO:0000269|PubMed:34789875, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}.,ADM,Human adrenomedullin is a 52 amino acid peptide (MW 6029) with the physiological effect of lowering blood pressure through vasodilatation, an effect it shares with calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). In addition adrenomedullin has other cardiovascular effects including growth and development of both cardiovascular tissues and bone, and has effects in the central nervous system connected with the regulation of fluid balance.

Molekulargewicht: 21 kDa (preproadrenomedullin), 6 kDa (mature peptide)

Gen-ID: 133

UniProt: P35318

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation