ube3a Antikörper (AA 1-860) (Fluoro594)

Produktnummer ABIN8052112

Der Fluoro594-konjugierte Maus Monoklonal anti-ube3a Antikörper (Klon 8I3) (ABIN8052112) detektiert spezifisch ube3a in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Affe.

Kurzübersicht für ube3a Antikörper (AA 1-860) (Fluoro594) (ABIN8052112)

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ube3a Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Klon: 8I3

Produktdetails anti-ube3a Antikörper (Fluoro594)

Bindungsspezifität: AA 1-860

Verwendungszweck: Anti-UBE3A Antibody (monoclonal, 8I3) Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human UBE3A recombinant protein (Position: M1-E860).

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Andere Bezeichnung: UBE3A

Hintergrund:

Background: Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Gene Full Name: ubiquitin protein ligase E3A

Gen-ID: 7337

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway