TFEB Antikörper (AA 50-461) (Fluoro647)

Produktnummer ABIN8047950

Der Kaninchen Polyklonal anti-TFEB Antikörper wird verwendet zum Nachweis von TFEB in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für TFEB Antikörper (AA 50-461) (Fluoro647) (ABIN8047950)

Target: TFEB (Transcription Factor EB (TFEB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TFEB Antikörper ist konjugiert mit Fluoro647

Applikation: Flow Cytometry (FACS)

Produktdetails anti-TFEB Antikörper (Fluoro647)

Bindungsspezifität: AA 50-461

Verwendungszweck: Anti-TFEB Antibody Fluoro647 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TFEB recombinant protein (Position: T50-A461).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Andere Bezeichnung: TFEB

Hintergrund:

Background: Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes. TFEB overexpression in cultured cells induces lysosomal biogenesis, exocytosis and autophagy. Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington, Parkinson and Alzheimer diseases, resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes. TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease. TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals.

Gene Full Name: transcription factor EB

Gen-ID: 7942

UniProt: P19484