TIGAR Antikörper (AA 1-270) (HRP)

Produktnummer ABIN8047628

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TIGAR in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TIGAR Antikörper (AA 1-270) (HRP) (ABIN8047628)

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIGAR Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TIGAR Antikörper (HRP)

Bindungsspezifität: AA 1-270

Verwendungszweck: Anti-TIGAR Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TIGAR recombinant protein (Position: M1-R270). Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu TIGAR

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Andere Bezeichnung: TIGAR

Hintergrund:

Background: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene Full Name: TP53 induced glycolysis regulatory phosphatase

Gen-ID: 57103

UniProt: Q9NQ88

Pathways: Warburg Effekt