Thrombopoietin Antikörper (AA 22-258) (HRP)

Produktnummer ABIN8046341

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Thrombopoietin in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Thrombopoietin Antikörper (AA 22-258) (HRP) (ABIN8046341)

Target: Thrombopoietin (THPO)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thrombopoietin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Thrombopoietin Antikörper (HRP)

Bindungsspezifität: AA 22-258

Verwendungszweck: Anti-Thrombopoietin/THPO Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human Thrombopoietin,TPO recombinant protein (Position: S22-R258). Human Thrombopoietin,TPO shares 79.3%,80.6% amino acid (aa) sequence identity with mouse,rat Thrombopoietin,TPO,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Thrombopoietin/TPO recombinant protein (Position: S22-R258). Human Thrombopoietin/TPO shares 79.3% and 80.6% amino acid (aa) sequence identity with mouse and rat Thrombopoietin/TPO, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Thrombopoietin

Target: Thrombopoietin (THPO)

Andere Bezeichnung: THPO

Hintergrund:

Background: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

Gene Full Name: thrombopoietin

Gen-ID: 7066

UniProt: P40225

Pathways: JAK-STAT Signalweg, Hormone Activity