Tec Protein Tyrosine Kinase (TEC) (N-Term) Antikörper (Fluoro488)

Produktnummer ABIN8045620

Der Fluoro488-konjugierte Kaninchen Polyklonal anti-Tec Protein Tyrosine Kinase Antikörper (ABIN8045620) detektiert spezifisch Tec Protein Tyrosine Kinase in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Tec Protein Tyrosine Kinase (TEC) (N-Term) Antikörper (Fluoro488) (ABIN8045620)

Target: Tec Protein Tyrosine Kinase (TEC)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails

Bindungsspezifität: N-Term

Verwendungszweck: Anti-Tec Antibody Fluoro488 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Tec, which shares 97.5% amino acid (aa) sequence identity with both mouse and rat Tec.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Antigendetails

Target: Tec Protein Tyrosine Kinase (TEC)

Andere Bezeichnung: TEC

Hintergrund:

Background: TEC (TEC Protein Tyrosine Kinase) is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al. (1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al. (2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.

Gene Full Name: tec protein tyrosine kinase

Gen-ID: 7006

UniProt: P42680

Pathways: Fc-epsilon Rezeptor Signalübertragung