SSH1 Antikörper (AA 489-921) (HRP)

Produktnummer ABIN8037966

Der Kaninchen Polyklonal anti-SSH1 Antikörper wird verwendet zum Nachweis von SSH1 in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für SSH1 Antikörper (AA 489-921) (HRP) (ABIN8037966)

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSH1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SSH1 Antikörper (HRP)

Bindungsspezifität: AA 489-921

Verwendungszweck: Anti-SSH1 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human SSH1 shares 66.9% amino acid (aa) sequence identity with mouse SSH1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SSH1 recombinant protein (Position: E489-Y921). Human SSH1 shares 66.9% amino acid (aa) sequence identity with mouse SSH1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu SSH1

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Andere Bezeichnung: SSH1

Hintergrund:

Background: Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene. The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Full Name: slingshot protein phosphatase 1

Gen-ID: 54434

UniProt: Q8WYL5

Pathways: CXCR4-mediated Signaling Events