Serotonin Receptor 1A Antikörper (C-Term)

Produktnummer ABIN8036214

Der Kaninchen Polyklonal anti-Serotonin Receptor 1A Antikörper wird verwendet zum Nachweis von Serotonin Receptor 1A in Proben von Human und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für Serotonin Receptor 1A Antikörper (C-Term) (ABIN8036214)

Target: Serotonin Receptor 1A (HTR1A)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-Serotonin Receptor 1A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-5HT1A Receptor/HTR1A Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related rat,mouse sequences by one amino acid.

Produktmerkmale: Anti-5HT1A Receptor/HTR1A Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor, different from the related rat and mouse sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Rat

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Andere Bezeichnung: HTR1A

Hintergrund:

Background: HTR1A (5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Gene Full Name: 5-hydroxytryptamine receptor 1A

Sequence Similarities: Belongs to the WD repeat BUB3 family.

Molekulargewicht: 46 kDa

Gen-ID: 3350

UniProt: P08908

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour