Serotonin Receptor 1A Antikörper (C-Term) (Biotin)

Produktnummer ABIN8036204

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Serotonin Receptor 1A in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für Serotonin Receptor 1A Antikörper (C-Term) (Biotin) (ABIN8036204)

Target: Serotonin Receptor 1A (HTR1A)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 1A Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Serotonin Receptor 1A Antikörper (Biotin)

Bindungsspezifität: C-Term

Verwendungszweck: Anti-5HT1A Receptor/HTR1A Antibody Biotin Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related rat,mouse sequences by one amino acid.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor, different from the related rat and mouse sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Andere Bezeichnung: HTR1A

Hintergrund:

Background: HTR1A (5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Gene Full Name: 5-hydroxytryptamine receptor 1A

Sequence Similarities: Belongs to the WD repeat BUB3 family.

Gen-ID: 3350

UniProt: P08908

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour