RNF43 Antikörper (AA 24-197) (Biotin)

Produktnummer ABIN8033339

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RNF43 in ELISA, WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RNF43 Antikörper (AA 24-197) (Biotin) (ABIN8033339)

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF43 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-RNF43 Antikörper (Biotin)

Bindungsspezifität: AA 24-197

Verwendungszweck: Anti-RNF43 Antibody Biotin Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human RNF43 recombinant protein (Position: G24-Y197).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu RNF43

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Andere Bezeichnung: RNF43

Hintergrund:

Background: RNF43 is a HAP95 (AKAP8L) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer. The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: ring finger protein 43

Gen-ID: 54894

UniProt: Q68DV7

Pathways: WNT Signalweg