REST Antikörper (AA 110-1097) (FITC)

Produktnummer ABIN8030842

Der FITC-konjugierte Kaninchen Polyklonal anti-REST Antikörper (ABIN8030842) detektiert spezifisch REST in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für REST Antikörper (AA 110-1097) (FITC) (ABIN8030842)

Target: REST (RE1-Silencing Transcription Factor (REST))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser REST Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-REST Antikörper (FITC)

Bindungsspezifität: AA 110-1097

Verwendungszweck: Anti-REST Antibody FITC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human REST shares 62.9%,59.6% amino acid (aa) sequence identity with mouse,rat REST,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human REST recombinant protein (Position: E110-E1097). Human REST shares 62.9% and 59.6% amino acid (aa) sequence identity with mouse and rat REST, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu REST

Target: REST (RE1-Silencing Transcription Factor (REST))

Andere Bezeichnung: REST

Hintergrund:

Background: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.

Gene Full Name: RE1 silencing transcription factor

Gen-ID: 5978

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity