Prolactin Receptor Antikörper (C-Term) (Fluoro488)

Produktnummer ABIN8025763

Der Fluoro488-konjugierte Kaninchen Polyklonal anti-Prolactin Receptor Antikörper (ABIN8025763) detektiert spezifisch Prolactin Receptor in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Prolactin Receptor Antikörper (C-Term) (Fluoro488) (ABIN8025763)

Target: Prolactin Receptor (PRLR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prolactin Receptor Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Prolactin Receptor Antikörper (Fluoro488)

Bindungsspezifität: C-Term

Verwendungszweck: Anti-Prolactin Receptor/PRLR Antibody Fluoro488 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by eleven amino acids,and from the related rat sequence by fourteen amino acids.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PRLR, different from the related mouse sequence by eleven amino acids, and from the related rat sequence by fourteen amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Prolactin Receptor

Target: Prolactin Receptor (PRLR)

Andere Bezeichnung: PRLR

Hintergrund:

Background: PRLR (Prolactin Receptor) is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al. (1989, 1990) demonstrated that the prolactin receptor gene resides in the same chromosomal region as the growth hormone receptor gene, which has been mapped to 5p13-p12. Cunningham et al. (1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to the growth hormone receptor or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues (histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRL receptors but not GH receptors) are likely zinc-ion ligands.

Gene Full Name: prolactin receptor

Gen-ID: 5618

UniProt: P16471

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus