PTRF Antikörper (AA 47-390) (PE)

Produktnummer ABIN8024361

Der Kaninchen Polyklonal anti-PTRF Antikörper wird verwendet zum Nachweis von PTRF in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für PTRF Antikörper (AA 47-390) (PE) (ABIN8024361)

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTRF Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-PTRF Antikörper (PE)

Bindungsspezifität: AA 47-390

Verwendungszweck: Anti-PTRF/CAVIN1 Antibody PE Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PTRF/CAVIN1 recombinant protein (Position: D47-D390).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PTRF

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Andere Bezeichnung: CAVIN1

Hintergrund:

Background: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Gene Full Name: caveolae associated protein 1

Gen-ID: 284119

UniProt: Q6NZI2