PLAUR Antikörper (AA 25-261) (APC)

Produktnummer ABIN8022930

Der Kaninchen Polyklonal anti-PLAUR Antikörper wird verwendet zum Nachweis von PLAUR in Proben von Ratte und Maus. Er wurde validiert für FACS.

Kurzübersicht für PLAUR Antikörper (AA 25-261) (APC) (ABIN8022930)

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLAUR Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-PLAUR Antikörper (APC)

Bindungsspezifität: AA 25-261

Verwendungszweck: Anti-uPA Receptor/Plaur Antibody APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived rat uPA Receptor recombinant protein (Position: L25-R261).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PLAUR

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Andere Bezeichnung: Plaur

Hintergrund:

Background: PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

Gene Full Name: plasminogen activator, urokinase receptor

Gen-ID: 50692

UniProt: P49616

Pathways: Inositol Metabolic Process