PHGDH Antikörper (AA 15-533) (Biotin)

Produktnummer ABIN8021691

Der Kaninchen Polyklonal anti-PHGDH Antikörper wird verwendet zum Nachweis von PHGDH in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für PHGDH Antikörper (AA 15-533) (Biotin) (ABIN8021691)

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHGDH Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PHGDH Antikörper (Biotin)

Bindungsspezifität: AA 15-533

Verwendungszweck: Anti-PHGDH Antibody Biotin Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human PHGDH shares 94.4%,94.2% amino acid (aa) sequence identity with mouse,rat PHGDH,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PHGDH recombinant protein (Position: L15-F533). Human PHGDH shares 94.4% and 94.2% amino acid (aa) sequence identity with mouse and rat PHGDH, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PHGDH

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Andere Bezeichnung: PHGDH

Hintergrund:

Background: This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Gene Full Name: phosphoglycerate dehydrogenase

Gen-ID: 26227

UniProt: O43175

Pathways: Metabolism of Steroid Hormones and Vitamin D, Warburg Effekt