PARK7/DJ1 Antikörper (AA 2-189) (Fluoro647)

Produktnummer ABIN8019678

Der Maus Monoklonal anti-PARK7/DJ1 Antikörper wird verwendet zum Nachweis von PARK7/DJ1 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für PARK7/DJ1 Antikörper (AA 2-189) (Fluoro647) (ABIN8019678)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PARK7/DJ1 Antikörper ist konjugiert mit Fluoro647

Applikation: Flow Cytometry (FACS)

Klon: 4B10

Produktdetails anti-PARK7/DJ1 Antikörper (Fluoro647)

Bindungsspezifität: AA 2-189

Verwendungszweck: Anti-PARK7/DJ1 Antibody (monoclonal, 4B10) Fluoro647 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse,rat PARK7.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PARK7 recombinant protein (Position: A2-D189). Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse and rat PARK7.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Andere Bezeichnung: PARK7

Hintergrund:

Background: Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.

Gene Full Name: Parkinsonism associated deglycase

Gen-ID: 11315

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport