ORC2 Antikörper (AA 130-493) (APC)

Produktnummer ABIN8018376

Der Kaninchen Polyklonal anti-ORC2 Antikörper wird verwendet zum Nachweis von ORC2 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für ORC2 Antikörper (AA 130-493) (APC) (ABIN8018376)

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORC2 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-ORC2 Antikörper (APC)

Bindungsspezifität: AA 130-493

Verwendungszweck: Anti-ORC2 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human ORC2 shares 80.2%,79.4% amino acid (aa) sequence identity with mouse,rat ORC2,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ORC2 recombinant protein (Position: E130-R493). Human ORC2 shares 80.2% and 79.4% amino acid (aa) sequence identity with mouse and rat ORC2, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu ORC2

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Andere Bezeichnung: ORC2

Hintergrund:

Background: Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.

Gene Full Name: origin recognition complex subunit 2

Gen-ID: 4999

UniProt: Q13416