Oncostatin M Antikörper (AA 55-158) (HRP)

Produktnummer ABIN8018087

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Oncostatin M in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für Oncostatin M Antikörper (AA 55-158) (HRP) (ABIN8018087)

Target: Oncostatin M (OSM)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oncostatin M Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Oncostatin M Antikörper (HRP)

Bindungsspezifität: AA 55-158

Verwendungszweck: Anti-Osm Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Rat Osm shares 46%,71.2% amino acid (aa) sequence identity with human,mouse Osm,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived rat Osm recombinant protein (Position: E55-D158). Rat Osm shares 46% and 71.2% amino acid (aa) sequence identity with human and mouse Osm, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Oncostatin M

Target: Oncostatin M (OSM)

Andere Bezeichnung: Osm

Hintergrund:

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Gene Full Name: oncostatin M

Gen-ID: 289747

UniProt: Q65Z15

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion