Oncostatin M Antikörper (AA 26-220) (Cy3)

Produktnummer ABIN8018049

Der Kaninchen Polyklonal anti-Oncostatin M Antikörper wird verwendet zum Nachweis von Oncostatin M in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für Oncostatin M Antikörper (AA 26-220) (Cy3) (ABIN8018049)

Target: Oncostatin M (OSM)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oncostatin M Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Oncostatin M Antikörper (Cy3)

Bindungsspezifität: AA 26-220

Verwendungszweck: Anti-Oncostatin M/OSM Antibody Cy3 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human Oncostatin M recombinant protein (Position: A26-R220). Human Oncostatin M shares 47.1%,47.6% amino acid (aa) sequence identity with mouse,rat Oncostatin M,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Oncostatin M recombinant protein (Position: A26-R220). Human Oncostatin M shares 47.1% and 47.6% amino acid (aa) sequence identity with mouse and rat Oncostatin M, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Oncostatin M

Target: Oncostatin M (OSM)

Andere Bezeichnung: OSM

Hintergrund:

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Gene Full Name: oncostatin M

Gen-ID: 5008

UniProt: P13725

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion