NUMB Antikörper (AA 59-567) (Fluoro594)

Produktnummer ABIN8017788

Der Kaninchen Polyklonal anti-NUMB Antikörper wird verwendet zum Nachweis von NUMB in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für FACS.

Kurzübersicht für NUMB Antikörper (AA 59-567) (Fluoro594) (ABIN8017788)

Target: NUMB (Numb Homolog (NUMB))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMB Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Produktdetails anti-NUMB Antikörper (Fluoro594)

Bindungsspezifität: AA 59-567

Verwendungszweck: Anti-NUMB Antibody Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse,rat NUMB.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human NUMB recombinant protein (Position: E59-A567). Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse and rat NUMB.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu NUMB

Target: NUMB (Numb Homolog (NUMB))

Andere Bezeichnung: NUMB

Hintergrund:

Background: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. What's more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Gene Full Name: NUMB endocytic adaptor protein

Gen-ID: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization