MLKL Antikörper (AA 210-464) (Fluoro647)

Produktnummer ABIN8011464

Der Kaninchen Polyklonal anti-MLKL Antikörper wird verwendet zum Nachweis von MLKL in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für MLKL Antikörper (AA 210-464) (Fluoro647) (ABIN8011464)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLKL Antikörper ist konjugiert mit Fluoro647

Applikation: Flow Cytometry (FACS)

Produktdetails anti-MLKL Antikörper (Fluoro647)

Bindungsspezifität: AA 210-464

Verwendungszweck: Anti-MLKL Antibody Fluoro647 Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human MLKL shares 69.7% amino acid (aa) sequence identity with mouse MLKL.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MLKL recombinant protein (Position: R210-K464). Human MLKL shares 69.7% amino acid (aa) sequence identity with mouse MLKL.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Andere Bezeichnung: MLKL

Hintergrund:

Background: Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Gene Full Name: mixed lineage kinase domain like pseudokinase

Gen-ID: 197259

UniProt: Q8NB16