MFGE8 Antikörper (AA 23-463) (HRP)

Produktnummer ABIN8010218

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MFGE8 in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für MFGE8 Antikörper (AA 23-463) (HRP) (ABIN8010218)

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MFGE8 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MFGE8 Antikörper (HRP)

Bindungsspezifität: AA 23-463

Verwendungszweck: Anti-Milk Fat Globule 1/Mfge8 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Mouse?Mfge8 shares?86.2%?amino?acid?(aa)?sequence?identity?with rat Mfge8.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Milk Fat Globule 1/Mfge8 recombinant protein (Position: A23-C463). Mouse?Mfge8 shares?86.2%?amino?acid?(aa)?sequence?identity?with rat Mfge8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu MFGE8

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Andere Bezeichnung: Mfge8

Hintergrund:

Background: MFGE8 (Milk Fat Globule-Egf Factor 8), also called as Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. Mfge8 is secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al. (1997) mapped the MFGE8 gene to chromosome 15q25. Hanayama et al. (2002) found that MFGE8 is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. MFGE8, when engaged by phospholipids, bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al. (2007) showed that Mfge8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that Mfge8 promoted migration of intestinal epithelial cells through a PKC-epsilon (PRKCE)-dependent mechanism.

Gene Full Name: milk fat globule EGF and factor V/VIII domain containing

Gen-ID: 17304

UniProt: P21956

Pathways: SARS-CoV-2 Protein Interaktom