MMP12 Antikörper (AA 237-442) (Fluoro594)

Produktnummer ABIN8008059

Der Kaninchen Polyklonal anti-MMP12 Antikörper wird verwendet zum Nachweis von MMP12 in Proben von Maus. Er wurde validiert für FACS.

Kurzübersicht für MMP12 Antikörper (AA 237-442) (Fluoro594) (ABIN8008059)

Target: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP12 Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Produktdetails anti-MMP12 Antikörper (Fluoro594)

Bindungsspezifität: AA 237-442

Verwendungszweck: Anti-Mmp12 Antibody Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Mouse Mmp12 shares 62.7%,90.3% amino acid (aa) sequence identity with mouse,rat Mmp12,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Mmp12 recombinant protein (Position: K237-H442). Mouse Mmp12 shares 62.7% and 90.3% amino acid (aa) sequence identity with mouse and rat Mmp12, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu MMP12

Target: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Andere Bezeichnung: Mmp12

Hintergrund:

Background: Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

Gene Full Name: matrix metallopeptidase 12

Gen-ID: 17381

UniProt: P34960