MASP1 Antikörper (AA 169-580) (APC)

Produktnummer ABIN8007644

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MASP1 in FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für MASP1 Antikörper (AA 169-580) (APC) (ABIN8007644)

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MASP1 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-MASP1 Antikörper (APC)

Bindungsspezifität: AA 169-580

Verwendungszweck: Anti-MASP1 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human MASP1 shares 84.5%,83.3% amino acid (aa) sequence identity with mouse,rat MASP1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MASP1 recombinant protein (Position: R169-E580). Human MASP1 shares 84.5% and 83.3% amino acid (aa) sequence identity with mouse and rat MASP1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Andere Bezeichnung: MASP1

Hintergrund:

Background: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Gene Full Name: MBL associated serine protease 1

Gen-ID: 5648

UniProt: P48740

Pathways: Komplementsystem