ITM2C Antikörper (AA 33-226) (HRP)

Produktnummer ABIN8000248

Der HRP-konjugierte Kaninchen Polyklonal anti-ITM2C Antikörper (ABIN8000248) detektiert spezifisch ITM2C in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für ITM2C Antikörper (AA 33-226) (HRP) (ABIN8000248)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITM2C Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ITM2C Antikörper (HRP)

Bindungsspezifität: AA 33-226

Verwendungszweck: Anti-ITM2C Antibody HRP Conjugated

Homologie: Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse,rat ITM2C.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ITM2C recombinant protein (Position: E33-D226). Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Andere Bezeichnung: ITM2C

Hintergrund:

Background: Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Gene Full Name: integral membrane protein 2C

Gen-ID: 81618

UniProt: Q9NQX7