Huntingtin Antikörper (AA 3079-3142)

Produktnummer ABIN7998432

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Huntingtin in IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Huntingtin Antikörper (AA 3079-3142) (ABIN7998432)

Target: Huntingtin (HTT)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Huntingtin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Güteklasse: Carrier-free

Produktdetails anti-Huntingtin Antikörper

Bindungsspezifität: AA 3079-3142

Verwendungszweck: Anti-Huntingtin/HTT Antibody

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human HTT shares 93.8%,92.2% amino acid (aa) sequence identity with mouse,rat HTT,respectively.

Produktmerkmale: Anti-Huntingtin/HTT Antibody. Tested in ELISA, IHC applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Huntingtin/HTT recombinant protein (Position: R3079-C3142). Human HTT shares 93.8% and 92.2% amino acid (aa) sequence identity with mouse and rat HTT, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Huntingtin

Target: Huntingtin (HTT)

Andere Bezeichnung: HTT

Hintergrund:

Background: The huntingtin gene, also called HTT or HD(Huntington disease) gene, is the IT15(interesting transcript 15) gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor(BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

Gene Full Name: huntingtin

Molekulargewicht: 65 kDa

Gen-ID: 3064

UniProt: P42858

Pathways: PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport