FURIN Antikörper (AA 591-794) (PE)

Produktnummer ABIN7991997

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FURIN in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FURIN Antikörper (AA 591-794) (PE) (ABIN7991997)

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FURIN Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-FURIN Antikörper (PE)

Bindungsspezifität: AA 591-794

Verwendungszweck: Anti-Furin Antibody PE Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human Furin shares 88% amino acid (aa) sequence identity with both mouse,rat Furin.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Andere Bezeichnung: FURIN

Hintergrund:

Background: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.

Gene Full Name: furin, paired basic amino acid cleaving enzyme

Sequence Similarities: Belongs to the peptidase S8 family. Furin subfamily.

Gen-ID: 5045

UniProt: P09958

Pathways: Notch Signalweg, Neurotrophin Signalübertragung