FURIN Antikörper (AA 120-370)

Produktnummer ABIN6140815

Produktdetails anti-FURIN Antikörper

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Bindungsspezifität: AA 120-370

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FURIN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Sequenz: QQWYLSGVTQ RDLNVKAAWA QGYTGHGIVV SILDDGIEKN HPDLAGNYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA GEVAAVANNG VCGVGVAYNA RIGGVRMLDG EVTDAVEARS LGLNPNHIHI YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE HDSCNCDGYT NSIYTLSISS ATQFGNVPWY SEACSSTLAT TYSSGNQNEK QIVTTDLRQK CTESHTGTSA S

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-370 of human Furin (NP_002560.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Andere Bezeichnung: FURIN (FURIN Produkte)

Synonyme: FURIN antikoerper, furin antikoerper, si:dkey-281a24.5 antikoerper, FUR antikoerper, LOC100220259 antikoerper, PACE antikoerper, spc1 antikoerper, xfurin antikoerper, MGC82710 antikoerper, PCSK3 antikoerper, SPC1 antikoerper, 9130404I01Rik antikoerper, Fur antikoerper, Pcsk3 antikoerper, Pace antikoerper, furin, paired basic amino acid cleaving enzyme antikoerper, furin (paired basic amino acid cleaving enzyme) a antikoerper, furin (paired basic amino acid cleaving enzyme) b antikoerper, furin, paired basic amino acid cleaving enzyme L homeolog antikoerper, furin (paired basic amino acid cleaving enzyme) antikoerper, FURIN antikoerper, furina antikoerper, furinb antikoerper, furin antikoerper, furin.L antikoerper, Furin antikoerper

Hintergrund: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.,FURIN,FUR,PACE,PCSK3,SPC1,furin,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Ubiquitin,Notch Signaling Pathway,Endocrine & Metabolism,FURIN

Molekulargewicht: 86 kDa

Gen-ID: 5045

UniProt: P09958

Pathways: Notch Signalweg, Neurotrophin Signalübertragung