FRZB Antikörper (AA 176-325) (HRP)

Produktnummer ABIN7991896

Der Kaninchen Polyklonal anti-FRZB Antikörper wird verwendet zum Nachweis von FRZB in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für FRZB Antikörper (AA 176-325) (HRP) (ABIN7991896)

Target: FRZB (Frizzled-Related Protein (FRZB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRZB Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FRZB Antikörper (HRP)

Bindungsspezifität: AA 176-325

Verwendungszweck: Anti-FRZB Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu FRZB

Target: FRZB (Frizzled-Related Protein (FRZB))

Andere Bezeichnung: FRZB

Hintergrund:

Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Gene Full Name: frizzled related protein

Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.

Gen-ID: 2487

UniProt: Q92765

Pathways: WNT Signalweg, Positive Regulation of fat Cell Differentiation