FOXM1 Antikörper (AA 48-763) (HRP)

Produktnummer ABIN7991486

Der HRP-konjugierte Kaninchen Polyklonal anti-FOXM1 Antikörper (ABIN7991486) detektiert spezifisch FOXM1 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für FOXM1 Antikörper (AA 48-763) (HRP) (ABIN7991486)

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXM1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FOXM1 Antikörper (HRP)

Bindungsspezifität: AA 48-763

Verwendungszweck: Anti-FOXM1 Antibody HRP Conjugated

Homologie: Human FOXM1 shares 78.9%,81.1% amino acid (aa) sequence identity with mouse,rat FOXM1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXM1 recombinant protein (Position: K48-Q763). Human FOXM1 shares 78.9% and 81.1% amino acid (aa) sequence identity with mouse and rat FOXM1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu FOXM1

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Andere Bezeichnung: FOXM1

Hintergrund:

Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 brain washes normal cells to adopt cancer-like epigenome.

Gene Full Name: forkhead box M1

Gen-ID: 2305

UniProt: Q08050

Pathways: Positive Regulation of Response to DNA Damage Stimulus