SIRPA Antikörper (PE-Cy5)

Produktnummer ABIN749465

Der Kaninchen Polyklonal Anti-SIRPA-Antikörper wurde für WB und FACS validiert. Er ist geeignet, SIRPA in Proben von Human, Ratte, Maus, Rind (Kuh), Schwein und Hund zu detektieren.

Kurzübersicht für SIRPA Antikörper (PE-Cy5) (ABIN749465)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRPA Antikörper ist konjugiert mit PE-Cy5

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-SIRPA Antikörper (PE-Cy5)

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD172a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: SIRP Alpha

Hintergrund:

Synonyms: BIT, MFR, P84, SIRP, MYD-1, SHPS1, CD172A, PTPNS1, Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, SIRPA, MYD1

Background: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Molekulargewicht: 56kDa

Gen-ID: 140885

UniProt: P78324