ECSIT Antikörper (AA 83-339) (HRP)

Produktnummer ABIN7987117

Der Kaninchen Polyklonal anti-ECSIT Antikörper wird verwendet zum Nachweis von ECSIT in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für ECSIT Antikörper (AA 83-339) (HRP) (ABIN7987117)

Target: ECSIT

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ECSIT Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ECSIT Antikörper (HRP)

Bindungsspezifität: AA 83-339

Verwendungszweck: Anti-ECSIT Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ECSIT recombinant protein (Position: E83-S339).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu ECSIT

Target: ECSIT

Andere Bezeichnung: ECSIT

Hintergrund:

Background: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Gene Full Name: ECSIT signaling integrator

Gen-ID: 51295

UniProt: Q9BQ95

Pathways: TLR Signalweg, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom