DKC1 Antikörper (AA 19-447) (Cy3)

Produktnummer ABIN7986680

Der Cy3-konjugierte Kaninchen Polyklonal anti-DKC1 Antikörper (ABIN7986680) detektiert spezifisch DKC1 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für DKC1 Antikörper (AA 19-447) (Cy3) (ABIN7986680)

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DKC1 Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Produktdetails anti-DKC1 Antikörper (Cy3)

Bindungsspezifität: AA 19-447

Verwendungszweck: Anti-DKC1 Antibody Cy3 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human DKC1 shares 94.2%,87.9% amino acid (aa) sequence identity with mouse,rat DKC1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DKC1 recombinant protein (Position: R19-R447). Human DKC1 shares 94.2% and 87.9% amino acid (aa) sequence identity with mouse and rat DKC1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Andere Bezeichnung: DKC1

Hintergrund:

Background: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

Gene Full Name: dyskerin pseudouridine synthase 1

Gen-ID: 1736

UniProt: O60832

Pathways: Telomere Maintenance