DOCK3 Antikörper (AA 88-2006)

Produktnummer ABIN7984603

Der Kaninchen Polyklonal anti-DOCK3 Antikörper wird verwendet zum Nachweis von DOCK3 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB, FACS und IHC.

Kurzübersicht für DOCK3 Antikörper (AA 88-2006) (ABIN7984603)

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-DOCK3 Antikörper

Bindungsspezifität: AA 88-2006

Verwendungszweck: Anti-MOCA/DOCK3 Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human MOCA,DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA,DOCK3.

Produktmerkmale: Anti-MOCA/DOCK3 Antibody. Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006). Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Andere Bezeichnung: DOCK3

Hintergrund:

Background: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

Gene Full Name: dedicator of cytokinesis 3

Molekulargewicht: 233 kDa

Gen-ID: 1795

UniProt: Q8IZD9