DOCK3 Antikörper (AA 88-2006) (Biotin)

Produktnummer ABIN7984593

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DOCK3 in ELISA, WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für DOCK3 Antikörper (AA 88-2006) (Biotin) (ABIN7984593)

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-DOCK3 Antikörper (Biotin)

Bindungsspezifität: AA 88-2006

Verwendungszweck: Anti-MOCA/DOCK3 Antibody Biotin Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human MOCA,DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA,DOCK3.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006). Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Andere Bezeichnung: DOCK3

Hintergrund:

Background: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

Gene Full Name: dedicator of cytokinesis 3

Gen-ID: 1795

UniProt: Q8IZD9