LAG3 Antikörper (AA 210-260) (PE)

Produktnummer ABIN748518

Dieses Anti-LAG3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LAG3 in WB. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für LAG3 Antikörper (AA 210-260) (PE) (ABIN748518)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAG3 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB)

Produktdetails anti-LAG3 Antikörper (PE)

Bindungsspezifität: AA 210-260

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lymphocyte Activation Gene 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:20-100)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-LAG3 Antikörper (PE) (ABIN748518)

Parodi, Battaglia, Kalli, Ferrera, Conteduca, Tardito, Stringara, Ivaldi, Negrini, Borgonovo, Simonato, Traverso, Carmignani, Fenoglio, Filaci: "CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes." in: Cancer immunology, immunotherapy : CII, Vol. 62, Issue 5, pp. 851-62, (2013) (PubMed).

Details zu LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: Lymphocyte Activation Gene 3

Hintergrund:

Synonyms: CD223, Lymphocyte activation gene 3 protein, LAG-3, Lag3

Background: Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4.

Gen-ID: 297596

UniProt: Q5BK54

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints